Game Of Thrones: Blending Genres

So I was cruising around io9, which I am wont to do, and came across this article. The basic premise is that the TV show LOST had a mystery with it, and the opened the door to more complex TV, such as GAME OF THRONES (this is a vastly simplified summary, but you get the point). Anyway, it made me think: the stories I tend to like best do blend different tropes of genres. Heck, I've often described ACROSS THE UNIVERSE as a murder mystery in space--an intentional blend of genres.

It got me thinking about the books that do blend genres. Blending genres keeps a book interesting, and surprises a reader. Come for the sci fi, stay for the mystery.

HUNGER GAMES: a blend of dystopian with romance--and a little fantasy (muttations, anyone? The science isn't quite science here--it's more fantasy. Look at the Capital!)
GAME OF THRONES: fantasy, with a blend of dystopian (White Watchers are creepy, yo)
DOCTOR WHO: sci fi, with a blend of comedy and mystery
ENDER'S GAME: sci fi + mystery
THE ROAD: dystopian + family tale
DIVERGENT: dystopian + school tale (factions) + mystery
WITHER: dystopian + feminism
SHATTER ME: dystopian + super heroes
BLACK HOLE SUN: sci fi + action hero movie

Think about the best books you've read recently. I'm willing to bet that one of the key things that book did right was blend genres--you have the "setting" genre--the genre most people will classify it as, the easily recognizable genre. But there's a sub-genre in it that will add a layer of uniqueness to the story--and that's what stays with the reader.